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A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis.
Vartak, Supriya V; Hegde, Mahesh; Iyer, Divyaanka; Gaikwad, Snehal; Gopalakrishnan, Vidya; Srivastava, Mrinal; Karki, Subhas S; Choudhary, Bibha; Ray, Pritha; Santhoshkumar, T R; Raghavan, Sathees C.
Affiliation
  • Vartak SV; Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.
  • Hegde M; Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.
  • Iyer D; Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.
  • Gaikwad S; Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410 210, India.
  • Gopalakrishnan V; Institute of Bioinformatics and Applied Biotechnology, Electronics City, Bangalore 560 100, India; Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.
  • Srivastava M; Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.
  • Karki SS; Department of Pharmaceutical Chemistry, KLE University's College of Pharmacy, Bangalore 560 010, India.
  • Choudhary B; Institute of Bioinformatics and Applied Biotechnology, Electronics City, Bangalore 560 100, India.
  • Ray P; Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410 210, India.
  • Santhoshkumar TR; Rajiv Gandhi Centre for Biotechnology, Trivandrum 695 014, India.
  • Raghavan SC; Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India. Electronic address: sathees@biochem.iisc.ernet.in.
Biochem Pharmacol ; 122: 10-22, 2016 Dec 15.
Article in En | MEDLINE | ID: mdl-27693384
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Full text: 1 Database: MEDLINE Main subject: Thiadiazoles / Proto-Oncogene Proteins c-bcl-2 / Indoles / Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Thiadiazoles / Proto-Oncogene Proteins c-bcl-2 / Indoles / Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2016 Type: Article