Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials.

Popejoy, Myra W; Paterson, David L; Cloutier, Daniel; Huntington, Jennifer A; Miller, Benjamin; Bliss, Caleb A; Steenbergen, Judith N; Hershberger, Ellie; Umeh, Obiamiwe; Kaye, Keith S

Popejoy, Myra W; Paterson, David L; Cloutier, Daniel; Huntington, Jennifer A; Miller, Benjamin; Bliss, Caleb A; Steenbergen, Judith N; Hershberger, Ellie; Umeh, Obiamiwe; Kaye, Keith S.

Affiliation

Popejoy MW; Merck & Co., Inc., Kenilworth, NJ, USA myra.popejoy@merck.com.
Paterson DL; Center for Clinical Research, University of Queensland, Brisbane, Australia.
Cloutier D; Merck & Co., Inc., Kenilworth, NJ, USA.
Huntington JA; Merck & Co., Inc., Kenilworth, NJ, USA.
Miller B; Merck & Co., Inc., Kenilworth, NJ, USA.
Bliss CA; Merck & Co., Inc., Kenilworth, NJ, USA.
Steenbergen JN; Merck & Co., Inc., Kenilworth, NJ, USA.
Hershberger E; Merck & Co., Inc., Kenilworth, NJ, USA.
Umeh O; Merck & Co., Inc., Kenilworth, NJ, USA.
Kaye KS; Detroit Medical Center and Department of Medicine, Wayne State University, Detroit, MI, USA.

J Antimicrob Chemother ; 72(1): 268-272, 2017 01.

Article in En | MEDLINE | ID: mdl-27707990

Subject(s)

Anti-Infective Agents, Urinary/administration & dosage; Cephalosporins/administration & dosage; Escherichia coli Infections/drug therapy; Intraabdominal Infections/drug therapy; Klebsiella Infections/drug therapy; Penicillanic Acid/analogs & derivatives; Urinary Tract Infections/drug therapy; beta-Lactamase Inhibitors/administration & dosage; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Female; Genotype; Humans; Klebsiella pneumoniae/drug effects; Klebsiella pneumoniae/enzymology; Klebsiella pneumoniae/genetics; Levofloxacin/administration & dosage; Male; Meropenem; Metronidazole/administration & dosage; Middle Aged; Penicillanic Acid/administration & dosage; Tazobactam; Thienamycins/administration & dosage; Treatment Outcome; Young Adult; beta-Lactamases/genetics; beta-Lactamases/metabolism

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Database: MEDLINE Main subject: Urinary Tract Infections / Klebsiella Infections / Cephalosporins / Penicillanic Acid / Escherichia coli Infections / Intraabdominal Infections / Beta-Lactamase Inhibitors / Anti-Infective Agents, Urinary Type of study: Clinical_trials Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2017 Type: Article

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