Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer.

Lin, Jason L J; Wu, Chyuan-Chuan; Yang, Wei-Zen; Yuan, Hanna S

Lin, Jason L J; Wu, Chyuan-Chuan; Yang, Wei-Zen; Yuan, Hanna S.

Affiliation

Lin JL; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 11529, ROC.
Wu CC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 11529, ROC.
Yang WZ; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 11529, ROC.
Yuan HS; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 11529, ROC hanna@sinica.edu.tw.

Nucleic Acids Res ; 44(21): 10480-10490, 2016 Dec 01.

Article in En | MEDLINE | ID: mdl-27738134

Subject(s)

DNA/chemistry; Endodeoxyribonucleases/chemistry; Amino Acid Sequence; DNA/metabolism; DNA, Single-Stranded/chemistry; DNA, Single-Stranded/metabolism; Endodeoxyribonucleases/genetics; Endodeoxyribonucleases/metabolism; Enzyme Activation; Hydrolysis; Models, Molecular; Molecular Conformation; Mutation; Protein Binding; Protein Multimerization; Structure-Activity Relationship

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