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Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity.
Pitta, Eleni; Balabon, Olga; Rogacki, Maciej K; Gómez, Jesús; Cunningham, Fraser; Joosens, Jurgen; Augustyns, Koen; van der Veken, Pieter; Bates, Robert.
Affiliation
  • Pitta E; Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, B-2610, Wilrijk, Belgium.
  • Balabon O; Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, B-2610, Wilrijk, Belgium.
  • Rogacki MK; Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, B-2610, Wilrijk, Belgium.
  • Gómez J; Diseases of the Developing World (DDW), Tres Cantos Medicines Development Campus (TCMDC), GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos Madrid, Spain.
  • Cunningham F; Diseases of the Developing World (DDW), Tres Cantos Medicines Development Campus (TCMDC), GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos Madrid, Spain.
  • Joosens J; Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, B-2610, Wilrijk, Belgium.
  • Augustyns K; Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, B-2610, Wilrijk, Belgium.
  • van der Veken P; Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, B-2610, Wilrijk, Belgium. Electronic address: pieter.vanderveken@uantwerpen.be.
  • Bates R; Diseases of the Developing World (DDW), Tres Cantos Medicines Development Campus (TCMDC), GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos Madrid, Spain. Electronic address: robert.h.bates@gsk.com.
Eur J Med Chem ; 125: 890-901, 2017 Jan 05.
Article in En | MEDLINE | ID: mdl-27769030
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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Magnetic Resonance Spectroscopy / Anti-Bacterial Agents / Mycobacteriaceae / Naphthyridines Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Magnetic Resonance Spectroscopy / Anti-Bacterial Agents / Mycobacteriaceae / Naphthyridines Language: En Year: 2017 Type: Article