Clinical application of SPECT in adrenal imaging with iodine-131 6 beta-iodomethyl-19-norcholesterol.
Clin Nucl Med
; 14(4): 278-81, 1989 Apr.
Article
in En
| MEDLINE
| ID: mdl-2785015
ABSTRACT
Forty-one patients with or without adrenocortical disorders were studied to evaluate the clinical usefulness of SPECT in adrenal imaging with I-131 Adosterol. In the SPECT images from this study, all glands with either normally functioning or hyperfunctioning adrenal cortices could be detected, while those glands with hypofunctioning adrenal cortices could not be detected. Particularly in transaxial and sagittal slices, the adrenal gland was identified posteriorly and was clearly distinguished from the gallbladder. In preliminary results using SPECT by a standard method, uptake in 68 detectable glands ranged from 1.7% to 4.9% in four glands with Cushing's syndrome, from 1.1% to 1.3% in seven glands with primary aldosteronism, and were distributed below 1.0% in the remaining glands with normally functioning adrenal cortices. These data show that it is possible to evaluate the adrenocortical functioning status simply by analyzing the SPECT images of the adrenal.
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Database:
MEDLINE
Main subject:
Tomography, Emission-Computed
/
Cholesterol
/
Adosterol
/
Adrenal Glands
/
Iodine Radioisotopes
Limits:
Humans
Language:
En
Year:
1989
Type:
Article