Bone Morphogenetic Protein 2 and Transforming Growth Factor ß1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts.

Chemel, Marguerite; Brion, Regis; Segaliny, Aude-Isabelle; Lamora, Audrey; Charrier, Celine; Brulin, Benedicte; Maugars, Yves; Le Goff, Benoit; Heymann, Dominique; Verrecchia, Franck

Chemel, Marguerite; Brion, Regis; Segaliny, Aude-Isabelle; Lamora, Audrey; Charrier, Celine; Brulin, Benedicte; Maugars, Yves; Le Goff, Benoit; Heymann, Dominique; Verrecchia, Franck.

Affiliation

Chemel M; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France; Musculoskeletal Department, Nantes University Hospital, Nantes, France.
Brion R; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France.
Segaliny AI; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France.
Lamora A; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France.
Charrier C; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France.
Brulin B; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France.
Maugars Y; Musculoskeletal Department, Nantes University Hospital, Nantes, France.
Le Goff B; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France; Musculoskeletal Department, Nantes University Hospital, Nantes, France.
Heymann D; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France; Musculoskeletal Department, Nantes University Hospital, Nantes, France; Department of Oncology and Metabolism, INSERM
Verrecchia F; French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France. Electronic address: franck.verrecchia@inserm.fr.

Am J Pathol ; 187(1): 156-162, 2017 Jan.

Article in En | MEDLINE | ID: mdl-27865758

Subject(s)

Arthritis, Rheumatoid/pathology; Bone Morphogenetic Protein 2/metabolism; Fibroblasts/metabolism; Inflammation/pathology; Interleukins/metabolism; Synovial Membrane/pathology; Transforming Growth Factor beta1/metabolism; Activin Receptors, Type II/metabolism; Adult; Aged; Aged, 80 and over; Animals; Female; Fibroblasts/pathology; Humans; Male; Mesenchymal Stem Cells/metabolism; Mice; Middle Aged; Models, Biological; Protein Serine-Threonine Kinases/metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/metabolism

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Full text: 1 Database: MEDLINE Main subject: Arthritis, Rheumatoid / Synovial Membrane / Interleukins / Transforming Growth Factor beta1 / Bone Morphogenetic Protein 2 / Fibroblasts / Inflammation Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Year: 2017 Type: Article

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