The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1.

Reuther, Clemens; Heinzle, Vera; Nölting, Svenja; Herterich, Sabine; Hahner, Stefanie; Halilovic, Ensar; Jeay, Sébastien; Wuerthner, Jens U; Aristizabal Prada, Elke Tatjana; Spöttl, Gerald; Maurer, Julian; Auernhammer, Christoph J

Reuther, Clemens; Heinzle, Vera; Nölting, Svenja; Herterich, Sabine; Hahner, Stefanie; Halilovic, Ensar; Jeay, Sébastien; Wuerthner, Jens U; Aristizabal Prada, Elke Tatjana; Spöttl, Gerald; Maurer, Julian; Auernhammer, Christoph J.

Affiliation

Reuther C; Department of Internal Medicine II, Campus Grosshadern, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Neuroendocrinology ; 106(1): 1-19, 2018.

Article in En | MEDLINE | ID: mdl-27871087

Subject(s)

Antineoplastic Agents/pharmacology; Fluorouracil/pharmacology; Isoquinolines/pharmacology; Neuroendocrine Tumors/drug therapy; Piperazines/pharmacology; Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors; Cell Line, Tumor; Cell Proliferation/drug effects; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Therapy, Combination; E2F1 Transcription Factor/metabolism; Humans; Neuroendocrine Tumors/genetics; Neuroendocrine Tumors/metabolism; Proto-Oncogene Proteins c-mdm2/metabolism; Retinoblastoma Protein/metabolism; Signal Transduction/drug effects; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism

Key words

5-Fluorouracil; Everolimus; GOT1; MDM2 inhibitor; NVP-CGM097; Neuroendocrine tumor; Temozolomide; p21; p53

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Full text: 1 Database: MEDLINE Main subject: Piperazines / Neuroendocrine Tumors / Proto-Oncogene Proteins c-mdm2 / Fluorouracil / Isoquinolines / Antineoplastic Agents Limits: Humans Language: En Year: 2018 Type: Article

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