The effects of general and spinal anesthesia on systemic inflammatory response in patients undergoing total knee arthroplasty.
Eklem Hastalik Cerrahisi
; 27(3): 153-9, 2016 Dec.
Article
in En
| MEDLINE
| ID: mdl-27902170
ABSTRACT
OBJECTIVES:
This study aims to compare the systemic inflammatory responses (SIRs) developing after total knee arthroplasty (TKA) performed under general or spinal anesthesia. PATIENTS ANDMETHODS:
This prospective study included 40 patients (8 males, 32 females; mean age 67.15±9.27 years; range 51 to 89 years) who underwent TKA in our clinic between February 2014 and July 2014. Patients were grouped to receive general (group 1, n=20) or spinal anesthesia (group 2, n=20). Levels of pro-inflammatory markers [Interleukin-6 (IL-6), IL-8, IL-1ß, tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP)] were studied from the venous blood samples obtained immediately before induction to anesthesia (T1), immediately after closure of the operative wound (T2), and at 24 hours postoperatively (T3).RESULTS:
In both groups, levels of CRP and IL-6 were significantly increased at T3 compared to those achieved at T1. Changes in the levels of TNF-α in both groups were similar. There were no significant differences between the groups in terms of the changes within the levels of the studied markers at the respective time intervals.CONCLUSION:
According to our study results, SIRs developing after TKA performed under general or spinal anesthesia are similar.
Full text:
1
Database:
MEDLINE
Main subject:
Systemic Inflammatory Response Syndrome
/
Arthroplasty, Replacement, Knee
/
Anesthesia, General
/
Anesthesia, Spinal
Type of study:
Observational_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Year:
2016
Type:
Article