Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation.

Rowlands, Benjamin D; Klugmann, Matthias; Rae, Caroline D

Rowlands, Benjamin D; Klugmann, Matthias; Rae, Caroline D.

Affiliation

Rowlands BD; Neuroscience Research Australia, Randwick, NSW, Australia.
Klugmann M; Translational Neuroscience Facility, School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia.
Rae CD; Neuroscience Research Australia, Randwick, NSW, Australia.

J Neurochem ; 140(6): 903-918, 2017 03.

Article in En | MEDLINE | ID: mdl-27925207

Subject(s)

Acetic Acid/metabolism; Astrocytes/metabolism; GABAergic Neurons/metabolism; Sirtuin 1/metabolism; gamma-Aminobutyric Acid/biosynthesis; Animals; Cerebral Cortex/metabolism; Female; Guinea Pigs; Organ Culture Techniques

Key words

Acetylation; GABA synthesis; acetate metabolism; compartmentation

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Full text: 1 Database: MEDLINE Main subject: Astrocytes / Acetic Acid / Sirtuin 1 / GABAergic Neurons / Gamma-Aminobutyric Acid Limits: Animals Language: En Year: 2017 Type: Article

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