Development of a More Efficient Albumin-Based Delivery System for Gambogic Acid with Low Toxicity for Lung Cancer Therapy.

Zhang, Yan; Yang, Zhijie; Tan, Xinyi; Tang, Xing; Yang, Zaixing

Zhang, Yan; Yang, Zhijie; Tan, Xinyi; Tang, Xing; Yang, Zaixing.

Affiliation

Zhang Y; Normal College, Shenyang University, No.54, Lianhe Road, Shenyang, 110044, China.
Yang Z; Kelun Pharmaceutical Co., Ltd, Tianjin, 300450, China.
Tan X; Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Tang X; Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Yang Z; Normal College, Shenyang University, No.54, Lianhe Road, Shenyang, 110044, China. yzx_syu@126.com.

AAPS PharmSciTech ; 18(6): 1987-1997, 2017 Aug.

Article in En | MEDLINE | ID: mdl-27933587

Subject(s)

Drug Carriers/toxicity; Lung Neoplasms/drug therapy; Serum Albumin/toxicity; Tumor Burden/drug effects; Xanthones/toxicity; A549 Cells; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/chemistry; Antineoplastic Agents/toxicity; Drug Carriers/chemistry; Drug Liberation; Humans; Lung Neoplasms/pathology; Male; Mice; Mice, SCID; Nanoparticles/chemistry; Particle Size; Serum Albumin/chemistry; Treatment Outcome; Tumor Burden/physiology; Xanthones/chemistry

Key words

antitumor; gambogic acid; human serum albumin; nanoparticles; stability

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Full text: 1 Database: MEDLINE Main subject: Serum Albumin / Drug Carriers / Xanthones / Tumor Burden / Lung Neoplasms Limits: Animals / Humans / Male Language: En Year: 2017 Type: Article

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