Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid-3 (TRPV3) Antagonist.

Voight, Eric A; Daanen, Jerome F; Schmidt, Robert G; Gomtsyan, Arthur; Dart, Michael J; Kym, Philip R.

Affiliation

Voight EA; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N Waukegan Rd, North Chicago, Illinois 60064, United States.
Daanen JF; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N Waukegan Rd, North Chicago, Illinois 60064, United States.
Schmidt RG; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N Waukegan Rd, North Chicago, Illinois 60064, United States.
Gomtsyan A; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N Waukegan Rd, North Chicago, Illinois 60064, United States.
Dart MJ; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N Waukegan Rd, North Chicago, Illinois 60064, United States.
Kym PR; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N Waukegan Rd, North Chicago, Illinois 60064, United States.

J Org Chem ; 81(23): 12060-12064, 2016 12 02.

Article in En | MEDLINE | ID: mdl-27934457

Subject(s)

TRPV Cation Channels/antagonists & inhibitors; Carbon-13 Magnetic Resonance Spectroscopy; Humans; Proton Magnetic Resonance Spectroscopy; Pyridines/chemistry; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

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