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Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors.
Saavedra, Oscar M; Karila, Delphine; Brossard, Dominique; Rojas, Anne; Dupuis, Delphine; Gohier, Arnaud; Mannoury la Cour, Clotilde; Millan, Mark J; Ortuno, Jean-Claude; Hanessian, Stephen.
Affiliation
  • Saavedra OM; Université de Montréal, Department of Chemistry, PO Box 6128, Station, Centre-ville, Montréal, Que. H3C 3J7, Canada.
  • Karila D; Université de Montréal, Department of Chemistry, PO Box 6128, Station, Centre-ville, Montréal, Que. H3C 3J7, Canada.
  • Brossard D; Université de Montréal, Department of Chemistry, PO Box 6128, Station, Centre-ville, Montréal, Que. H3C 3J7, Canada.
  • Rojas A; Chemistry Pole of Expertise, Institut de Recherches Servier, 3 rue de la République, 92150 Suresnes, France.
  • Dupuis D; Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier, 125 chemin de ronde, 78290 Croissy sur Seine, France.
  • Gohier A; Pole of Expertise Biotechnology-Chemistry-Biology, Institut de Recherches Servier, 125 chemin de ronde, 78290 Croissy sur Seine, France.
  • Mannoury la Cour C; Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier, 125 chemin de ronde, 78290 Croissy sur Seine, France.
  • Millan MJ; Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier, 125 chemin de ronde, 78290 Croissy sur Seine, France.
  • Ortuno JC; Chemistry Pole of Expertise, Institut de Recherches Servier, 3 rue de la République, 92150 Suresnes, France.
  • Hanessian S; Université de Montréal, Department of Chemistry, PO Box 6128, Station, Centre-ville, Montréal, Que. H3C 3J7, Canada.
Bioorg Med Chem ; 25(1): 38-52, 2017 01 01.
Article in En | MEDLINE | ID: mdl-28029458
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Full text: 1 Database: MEDLINE Main subject: Antipsychotic Agents / Drug Design / Receptors, Serotonin / Receptors, Dopamine D2 / Receptors, Dopamine D3 Limits: Humans Language: En Year: 2017 Type: Article
Fulltext
Print
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PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Antipsychotic Agents / Drug Design / Receptors, Serotonin / Receptors, Dopamine D2 / Receptors, Dopamine D3 Limits: Humans Language: En Year: 2017 Type: Article