The P2Y<sub>2</sub> nucleotide receptor is an inhibitor of vascular calcification.

Qian, Shaomin; Regan, Jenna N; Shelton, Maxwell T; Hoggatt, April; Mohammad, Khalid S; Herring, Paul B; Seye, Cheikh I

The P2Y₂ nucleotide receptor is an inhibitor of vascular calcification.

Qian, Shaomin; Regan, Jenna N; Shelton, Maxwell T; Hoggatt, April; Mohammad, Khalid S; Herring, Paul B; Seye, Cheikh I.

Affiliation

Qian S; Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Regan JN; Medicine/Endocrinology, Indiana University School of Medicine, Indianapolis, IN, USA.
Shelton MT; Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Hoggatt A; Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Mohammad KS; Medicine/Endocrinology, Indiana University School of Medicine, Indianapolis, IN, USA.
Herring PB; Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Seye CI; Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: cseye@iu.edu.

Atherosclerosis ; 257: 38-46, 2017 02.

Article in En | MEDLINE | ID: mdl-28038380

Subject(s)

Aortic Diseases/prevention & control; Atherosclerosis/prevention & control; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Receptors, Purinergic P2Y2/metabolism; Vascular Calcification/prevention & control; 5'-Nucleotidase/metabolism; Animals; Aorta/metabolism; Aorta/pathology; Aortic Diseases/genetics; Aortic Diseases/metabolism; Aortic Diseases/pathology; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Atherosclerosis/genetics; Atherosclerosis/metabolism; Atherosclerosis/pathology; Cell Transdifferentiation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit/genetics; Core Binding Factor Alpha 1 Subunit/metabolism; Disease Models, Animal; GPI-Linked Proteins/metabolism; Genetic Predisposition to Disease; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/pathology; Osteoblasts/metabolism; Osteoblasts/pathology; Osteocalcin/genetics; Osteocalcin/metabolism; Phenotype; Promoter Regions, Genetic; Receptors, Purinergic P2Y2/deficiency; Receptors, Purinergic P2Y2/genetics; Transfection; Vascular Calcification/genetics; Vascular Calcification/metabolism; Vascular Calcification/pathology

Key words

ATP; Atherosclerosis; Inflammation; Nucleotide receptor; Vascular calcification

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Full text: 1 Database: MEDLINE Main subject: Aortic Diseases / Myocytes, Smooth Muscle / Atherosclerosis / Receptors, Purinergic P2Y2 / Vascular Calcification / Muscle, Smooth, Vascular Type of study: Prognostic_studies Language: En Year: 2017 Type: Article

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