No Effect of SLCO1B1 and CYP3A4/5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Male Subjects.

Li, Mupeng; Hu, Yaodong; Li, Huilan; Wen, Zhipeng; Hu, Xiaolei; Zhang, Daoyu; Zhang, Yanjiao; Xiao, Jian; Tang, Jie; Chen, Xiaoping

Li, Mupeng; Hu, Yaodong; Li, Huilan; Wen, Zhipeng; Hu, Xiaolei; Zhang, Daoyu; Zhang, Yanjiao; Xiao, Jian; Tang, Jie; Chen, Xiaoping.

Affiliation

Li M; Department of Clinical Pharmacology, Xiangya Hospital, Central South University.

Biol Pharm Bull ; 40(1): 88-96, 2017.

Article in En | MEDLINE | ID: mdl-28049954

Subject(s)

Adenosine/analogs & derivatives; Cytochrome P-450 CYP3A/genetics; Liver-Specific Organic Anion Transporter 1/genetics; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Adenosine/blood; Adenosine/pharmacokinetics; Adenosine/pharmacology; Area Under Curve; Asian People/genetics; Genotype; Healthy Volunteers; Humans; Male; Platelet Aggregation/drug effects; Platelet Aggregation Inhibitors/blood; Platelet Aggregation Inhibitors/pharmacokinetics; Platelet Aggregation Inhibitors/pharmacology; Polymorphism, Single Nucleotide; Purinergic P2 Receptor Antagonists/blood; Purinergic P2 Receptor Antagonists/pharmacokinetics; Purinergic P2 Receptor Antagonists/pharmacology; Ticagrelor

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Full text: 1 Database: MEDLINE Main subject: Platelet Aggregation Inhibitors / Adenosine / Liver-Specific Organic Anion Transporter 1 / Cytochrome P-450 CYP3A / Purinergic P2 Receptor Antagonists Type of study: Prognostic_studies Limits: Humans / Male Language: En Year: 2017 Type: Article

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