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R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching.
Maul, Robert W; Chon, Hyongi; Sakhuja, Kiran; Cerritelli, Susana M; Gugliotti, Lina A; Gearhart, Patricia J; Crouch, Robert J.
Affiliation
  • Maul RW; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
  • Chon H; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Sakhuja K; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Cerritelli SM; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Gugliotti LA; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Gearhart PJ; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Electronic address: gearhartp@mail.nih.gov.
  • Crouch RJ; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address: crouchr@helix.nih.gov.
J Mol Biol ; 429(21): 3255-3263, 2017 10 27.
Article in En | MEDLINE | ID: mdl-28065739

Full text: 1 Database: MEDLINE Main subject: Recombination, Genetic / Immunoglobulin Isotypes / B-Lymphocytes / Immunoglobulin Class Switching / Ribonuclease H / Cytidine Deaminase / Nucleic Acid Conformation Limits: Animals Language: En Year: 2017 Type: Article

Full text: 1 Database: MEDLINE Main subject: Recombination, Genetic / Immunoglobulin Isotypes / B-Lymphocytes / Immunoglobulin Class Switching / Ribonuclease H / Cytidine Deaminase / Nucleic Acid Conformation Limits: Animals Language: En Year: 2017 Type: Article