Oxidative Recyclization of 1H-Indoles for Synthesis of 2-Indolylbenzoxazinones via Cleavage of the C2-C3 Bond with AIBN under Air.
J Org Chem
; 82(4): 2107-2113, 2017 02 17.
Article
in En
| MEDLINE
| ID: mdl-28121435
ABSTRACT
A novel and concise method for the oxidation of unprotected indole derivatives to synthesize 2-indolylbenzoxazinones in the presence of AIBN under open air has been successfully demonstrated. This metal-free reaction is both atom- and step-efficient and is applicable to a broad scope of substrates. This new methodology provides a facile pathway for oxidative C2-C3 bond cleavage and recyclization of 1H-indoles.
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Database:
MEDLINE
Language:
En
Year:
2017
Type:
Article