Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule.

Aaldering, Lukas J; Poongavanam, Vasanthanathan; Langkjaer, Niels; Murugan, N Arul; Jørgensen, Per Trolle; Wengel, Jesper; Veedu, Rakesh N.

Affiliation

Aaldering LJ; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
Poongavanam V; Institute for Plant Biology and Biotechnology, Westphalian Wilhelms University Münster, Schlossgarten 3, 48149, Münster, Germany.
Langkjaer N; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
Murugan NA; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
Jørgensen PT; Division of Theoretical Chemistry and Biology, School of Biotechnology, Royal Institute of Technology (KTH), 10691, Stockholm, Sweden.
Wengel J; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
Veedu RN; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

Chembiochem ; 18(8): 755-763, 2017 04 18.

Article in En | MEDLINE | ID: mdl-28150905

Subject(s)

Aptamers, Nucleotide/chemistry; Aptamers, Nucleotide/chemical synthesis; G-Quadruplexes; Blood Coagulation; Models, Chemical; Molecular Dynamics Simulation; Molecular Structure; Stochastic Processes

Key words

G-quadruplex; aptamers; modified DNA; thrombin; unlocked nucleic acid