Synthesis of 1ß-hydroxydeoxycholic acid in H-2 and unlabeled forms.

Hayes, Martin A; Roberts, Ieuan; Grönberg, Gunnar; Lv, Kexin; Lin, Baorui; Bergare, Jonas; Elmore, Charles S.

Affiliation

Hayes MA; Cardiovascular and Metabolic Diseases Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden.
Roberts I; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridgeshire, UK.
Grönberg G; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden.
Lv K; WuXi AppTec, Shanghai, China.
Lin B; WuXi AppTec, Shanghai, China.
Bergare J; Pharmaceutical Sciences Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden.
Elmore CS; Pharmaceutical Sciences Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden.

J Labelled Comp Radiopharm ; 60(4): 221-229, 2017 04.

Article in En | MEDLINE | ID: mdl-28183147

Subject(s)

Chenodeoxycholic Acid/analogs & derivatives; Deuterium/chemistry; Chemistry Techniques, Synthetic; Chenodeoxycholic Acid/chemical synthesis; Chenodeoxycholic Acid/chemistry; Cytochrome P-450 CYP3A/metabolism; Isotope Labeling

Key words

Cytochrome P450 3A4; NMR; Steroid; biocatalysis