Activation of contact-dependent antibacterial tRNase toxins by translation elongation factors.

Jones, Allison M; Garza-Sánchez, Fernando; So, Jaime; Hayes, Christopher S; Low, David A

Jones, Allison M; Garza-Sánchez, Fernando; So, Jaime; Hayes, Christopher S; Low, David A.

Affiliation

Jones AM; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.
Garza-Sánchez F; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.
So J; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.
Hayes CS; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.
Low DA; Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106.

Proc Natl Acad Sci U S A ; 114(10): E1951-E1957, 2017 03 07.

Article in En | MEDLINE | ID: mdl-28223500

Subject(s)

Endoribonucleases/chemistry; Enterohemorrhagic Escherichia coli/genetics; Escherichia coli Proteins/chemistry; Gene Expression Regulation, Bacterial; Membrane Proteins/chemistry; Peptide Elongation Factor Tu/chemistry; Peptide Elongation Factors/chemistry; RNA, Transfer/chemistry; Antibiosis/genetics; Base Sequence; Binding Sites; Contact Inhibition/genetics; Crystallography, X-Ray; Endoribonucleases/genetics; Endoribonucleases/metabolism; Enterohemorrhagic Escherichia coli/metabolism; Enterohemorrhagic Escherichia coli/pathogenicity; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Guanosine Triphosphate/chemistry; Guanosine Triphosphate/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Models, Molecular; Nucleic Acid Conformation; Peptide Elongation Factor Tu/genetics; Peptide Elongation Factor Tu/metabolism; Peptide Elongation Factors/genetics; Peptide Elongation Factors/metabolism; Protein Binding; Protein Biosynthesis; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; RNA, Transfer/metabolism; Substrate Specificity

Key words

bacterial competition; cell communication; protein synthesis; ribonuclease; toxin-immunity proteins

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Full text: 1 Database: MEDLINE Main subject: RNA, Transfer / Gene Expression Regulation, Bacterial / Peptide Elongation Factors / Peptide Elongation Factor Tu / Escherichia coli Proteins / Endoribonucleases / Enterohemorrhagic Escherichia coli / Membrane Proteins Type of study: Prognostic_studies Language: En Year: 2017 Type: Article

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