The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
Bull Exp Biol Med
; 162(4): 479-482, 2017 Feb.
Article
in En
| MEDLINE
| ID: mdl-28243914
ABSTRACT
Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Thymus Gland
/
Thymus Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Carcinogenesis
/
Mammary Neoplasms, Experimental
Limits:
Animals
Language:
En
Year:
2017
Type:
Article