Structural and functional insight into pan-endopeptidase inhibition by &#945;2-macroglobulins.

Goulas, Theodoros; Garcia-Ferrer, Irene; Marrero, Aniebrys; Marino-Puertas, Laura; Duquerroy, Stephane; Gomis-Rüth, F Xavier

Structural and functional insight into pan-endopeptidase inhibition by α2-macroglobulins.

Goulas, Theodoros; Garcia-Ferrer, Irene; Marrero, Aniebrys; Marino-Puertas, Laura; Duquerroy, Stephane; Gomis-Rüth, F Xavier.

Affiliation

Goulas T; .
Garcia-Ferrer I; .
Marrero A; .
Marino-Puertas L; .
Duquerroy S; .
Gomis-Rüth FX; .

Biol Chem ; 398(9): 975-994, 2017 08 28.

Article in En | MEDLINE | ID: mdl-28253193

Subject(s)

Endopeptidases/metabolism; Protease Inhibitors/chemistry; Protease Inhibitors/pharmacology; alpha-Macroglobulins/chemistry; alpha-Macroglobulins/pharmacology; Animals; Endopeptidases/chemistry; Humans; Protein Multimerization; Protein Structure, Quaternary

Key words

bait region cleavage; conformational rearrangement; irreversible inhibition; multi-domain protein; protein inhibitor; regulation of proteolytic activity

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Full text: 1 Database: MEDLINE Main subject: Endopeptidases / Protease Inhibitors / Alpha-Macroglobulins Limits: Animals / Humans Language: En Year: 2017 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Endopeptidases / Protease Inhibitors / Alpha-Macroglobulins Limits: Animals / Humans Language: En Year: 2017 Type: Article