BRCA1 Protein/chemistry; DNA Repair; Gene Expression Regulation, Neoplastic; Tumor Suppressor Proteins/chemistry; Ubiquitin-Protein Ligases/chemistry; BRCA1 Protein/genetics; BRCA1 Protein/metabolism; BRCA2 Protein/genetics; BRCA2 Protein/metabolism; Binding Sites; Cell Line, Tumor; DNA Damage; Female; Guanine/analogs & derivatives; Guanine/metabolism; Humans; Hydrogen Peroxide/pharmacology; Mammary Glands, Human/drug effects; Mammary Glands, Human/metabolism; Mammary Glands, Human/pathology; Models, Molecular; Molecular Imaging; Mutation; Oxidative Stress; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Structural Homology, Protein; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism