New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness.

Ritzefeld, Markus; Wright, Megan H; Tate, Edward W

Ritzefeld, Markus; Wright, Megan H; Tate, Edward W.

Affiliation

Ritzefeld M; Department of Chemistry,Imperial College London,London SW7 2AZ,UK.
Wright MH; School of Chemistry, University of Leeds,Leeds LS2 9JT,UK.
Tate EW; Department of Chemistry,Imperial College London,London SW7 2AZ,UK.

Parasitology ; 145(2): 157-174, 2018 02.

Article in En | MEDLINE | ID: mdl-28270257

Subject(s)

Drug Delivery Systems/methods; Leishmania donovani/drug effects; Plasmodium falciparum/drug effects; Protozoan Proteins/metabolism; Acylation/drug effects; Humans; Leishmania donovani/enzymology; Leishmania donovani/metabolism; Leishmaniasis/drug therapy; Malaria, Falciparum/drug therapy; Plasmodium falciparum/enzymology; Plasmodium falciparum/metabolism; Protein Processing, Post-Translational; Protein Transport; Proteomics/methods; Transferases/antagonists & inhibitors; Transferases/drug effects; Trypanosomiasis, African/drug therapy; Trypanosomiasis, African/parasitology

Key words

N-myristoyl transferase; NMT; acyl transferase; palmitoylation; post-translational modification; protein lipidation; proteomics; protozoan parasites; small molecule inhibitor

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Full text: 1 Database: MEDLINE Main subject: Plasmodium falciparum / Leishmania donovani / Protozoan Proteins / Drug Delivery Systems Limits: Humans Language: En Year: 2018 Type: Article

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