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Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial.
Soare, Andreea; Khazrai, Yeganeh Manon; Fontana, Lucia; Del Toro, Rossella; Lazzaro, Maria Concetta; Di Rosa, Claudia; Buldo, Antonia; Fioriti, Elvira; Maddaloni, Ernesto; Angeletti, Silvia; Di Mauro, Antonio; Gesuita, Rosaria; Skrami, Edlira; Tuccinardi, Dario; Fallucca, Sara; Pianesi, Mario; Pozzilli, Paolo.
Affiliation
  • Soare A; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Khazrai YM; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Fontana L; Unit of Dietology and Diabetology, Sandro Pertini Hospital, Rome, Italy.
  • Del Toro R; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Lazzaro MC; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Di Rosa C; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Buldo A; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Fioriti E; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Maddaloni E; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Angeletti S; Laboratory of Clinical Pathology and Microbiology, Campus Bio-Medico University of Rome, Rome, Italy.
  • Di Mauro A; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Gesuita R; Center of Epidemiology, Biostatistics and Medical Information Technology, Polytechnic Marche University, Ancona, Italy.
  • Skrami E; Center of Epidemiology, Biostatistics and Medical Information Technology, Polytechnic Marche University, Ancona, Italy.
  • Tuccinardi D; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Fallucca S; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Pianesi M; International Study Center for Environment, Agriculture, Food, Health and Economics, Tolentino, Italy.
  • Pozzilli P; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy; Centre for Immunobiology, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK. Electronic address: p.pozzilli@unicampus.it.
Metabolism ; 69: 148-156, 2017 Apr.
Article in En | MEDLINE | ID: mdl-28285645
ABSTRACT
BACKGROUND AND

AIMS:

Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by hypoglycemia that occurs within four hours after a meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type 2 diabetes. We explored the effect of this diet on outcomes in non-diabetic individuals with RH. MATERIALS AND

METHODS:

Twelve subjects with RH were randomized to the Ma-Pi 2 diet for three days and a control diet for three days in a randomized crossover design. Subjects received snacks on two days out of each three-day period only, and were monitored using continuous glucose monitoring. The 24-h period was divided into daytime (0800-2230h [subdivided into 'daytime without snacks' and 'daytime with snacks']) and night-time (2231-0759h). The effects of the two diets on the number of RH events (blood glucose <70mg/dL [3.9mmol/L]) and the percentage distribution of glucose readings within each of 16 glycemic intervals from <40mg/dL (2.2mmol/L) to >180mg/dL (4.4mmol/L) were determined.

RESULTS:

There were significantly fewer RH events on the Ma-Pi 2 diet than the control diet during daytime without snacks (-2.5 events; 95% CI -7.5, 0.0; P=0.022) and daytime with snacks (-4.25 events; 95% CI -7.5; -2.0; P=0.013) but no difference at night. The percentage of glucose readings in the interval 71-80mg/dL (3.9-4.4mmol/L) was significantly higher on the control diet during daytime with and without snacks (P=0.03 for both), while the percentage of glucose readings in the interval 91-100mg/dL (5.1-5.6mmol/L) was significantly higher on the Ma-Pi 2 diet during daytime without snacks (P=0.02).

CONCLUSIONS:

The macrobiotic Ma-Pi 2 diet reduced blood glucose excursions during the day, thereby facilitating glycemic control in subjects with RH. The Ma-Pi 2 diet represents an effective nutritional tool for management of RH.
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Full text: 1 Database: MEDLINE Main subject: Blood Glucose / Diet, Macrobiotic / Hypoglycemia Type of study: Clinical_trials Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Blood Glucose / Diet, Macrobiotic / Hypoglycemia Type of study: Clinical_trials Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2017 Type: Article