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Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.
Styrkarsdottir, Unnur; Helgason, Hannes; Sigurdsson, Asgeir; Norddahl, Gudmundur L; Agustsdottir, Arna B; Reynard, Louise N; Villalvilla, Amanda; Halldorsson, Gisli H; Jonasdottir, Aslaug; Magnusdottir, Audur; Oddson, Asmundur; Sulem, Gerald; Zink, Florian; Sveinbjornsson, Gardar; Helgason, Agnar; Johannsdottir, Hrefna S; Helgadottir, Anna; Stefansson, Hreinn; Gretarsdottir, Solveig; Rafnar, Thorunn; Almdahl, Ina S; Brækhus, Anne; Fladby, Tormod; Selbæk, Geir; Hosseinpanah, Farhad; Azizi, Fereidoun; Koh, Jung Min; Tang, Nelson L S; Daneshpour, Maryam S; Mayordomo, Jose I; Welt, Corrine; Braund, Peter S; Samani, Nilesh J; Kiemeney, Lambertus A; Lohmander, L Stefan; Christiansen, Claus; Andreassen, Ole A; Magnusson, Olafur; Masson, Gisli; Kong, Augustine; Jonsdottir, Ingileif; Gudbjartsson, Daniel; Sulem, Patrick; Jonsson, Helgi; Loughlin, John; Ingvarsson, Thorvaldur; Thorsteinsdottir, Unnur; Stefansson, Kari.
Affiliation
  • Styrkarsdottir U; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Helgason H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Sigurdsson A; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
  • Norddahl GL; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Agustsdottir AB; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Reynard LN; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Villalvilla A; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
  • Halldorsson GH; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
  • Jonasdottir A; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Magnusdottir A; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Oddson A; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Sulem G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Zink F; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Sveinbjornsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Helgason A; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Johannsdottir HS; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Helgadottir A; Department of Anthropology, University of Iceland, Reykjavik, Iceland.
  • Stefansson H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Gretarsdottir S; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Rafnar T; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Almdahl IS; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Brækhus A; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Fladby T; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
  • Selbæk G; Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
  • Hosseinpanah F; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
  • Azizi F; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
  • Koh JM; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Tang NLS; Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
  • Daneshpour MS; Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Mayordomo JI; Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, Ottestad, Norway.
  • Welt C; Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Braund PS; Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Samani NJ; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Kiemeney LA; Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Lohmander LS; Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Christiansen C; Division of Medical Oncology, Lozano Blesa University Hospital, Zaragoza, Spain.
  • Andreassen OA; Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, USA.
  • Magnusson O; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
  • Masson G; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Kong A; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
  • Jonsdottir I; Radboud University Medical Center, Radboud Institute for Health Science, Nijmegen, the Netherlands.
  • Gudbjartsson D; Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
  • Sulem P; Nordic Bioscience, Herlev, Denmark.
  • Jonsson H; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Ingvarsson T; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Thorsteinsdottir U; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Nat Genet ; 49(5): 801-805, 2017 May.
Article in En | MEDLINE | ID: mdl-28319091
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Full text: 1 Database: MEDLINE Main subject: Osteoarthritis, Hip / Genome, Human / Extracellular Matrix Proteins / Sequence Analysis, DNA / Genetic Predisposition to Disease / Cartilage Oligomeric Matrix Protein Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Europa Language: En Year: 2017 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Osteoarthritis, Hip / Genome, Human / Extracellular Matrix Proteins / Sequence Analysis, DNA / Genetic Predisposition to Disease / Cartilage Oligomeric Matrix Protein Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Europa Language: En Year: 2017 Type: Article