Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-&#945;-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.

Kobayashi, Mamiko; Mikami, Daisuke; Kimura, Hideki; Kamiyama, Kazuko; Morikawa, Yukie; Yokoi, Seiji; Kasuno, Kenji; Takahashi, Naoki; Taniguchi, Takanobu; Iwano, Masayuki

Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.

Kobayashi, Mamiko; Mikami, Daisuke; Kimura, Hideki; Kamiyama, Kazuko; Morikawa, Yukie; Yokoi, Seiji; Kasuno, Kenji; Takahashi, Naoki; Taniguchi, Takanobu; Iwano, Masayuki.

Affiliation

Kobayashi M; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Mikami D; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. Electronic address: dmikami@u-fukui.ac.jp.
Kimura H; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Department of Clinical Laboratory, University of Fukui Hospital, Fukui, Japan.
Kamiyama K; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Morikawa Y; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yokoi S; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Kasuno K; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Takahashi N; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Taniguchi T; Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Iwano M; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Biochem Biophys Res Commun ; 486(2): 499-505, 2017 04 29.

Article in En | MEDLINE | ID: mdl-28322790

Subject(s)

Chemokine CCL2/genetics; Epithelial Cells/drug effects; Fatty Acids, Volatile/pharmacology; MAP Kinase Kinase 4/genetics; Receptors, Cell Surface/genetics; Receptors, G-Protein-Coupled/genetics; Tumor Necrosis Factor-alpha/genetics; p38 Mitogen-Activated Protein Kinases/genetics; Cell Line; Chemokine CCL2/metabolism; Epithelial Cells/metabolism; Epithelial Cells/pathology; Fatty Acids, Volatile/metabolism; Gene Expression Regulation; Glomerulonephritis/genetics; Glomerulonephritis/metabolism; Glomerulonephritis/pathology; Humans; Kidney Cortex/drug effects; Kidney Cortex/metabolism; Kidney Cortex/pathology; Kidney Tubules, Collecting/metabolism; Kidney Tubules, Collecting/pathology; MAP Kinase Kinase 4/metabolism; Phosphorylation/drug effects; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Receptors, Cell Surface/metabolism; Receptors, G-Protein-Coupled/metabolism; Signal Transduction; Tumor Necrosis Factor-alpha/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

GPR41; GPR43; JNK; Monocyte chemoattractant protein-1; SCFA; p38

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Full text: 1 Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Receptors, Cell Surface / Chemokine CCL2 / Receptors, G-Protein-Coupled / MAP Kinase Kinase 4 / P38 Mitogen-Activated Protein Kinases / Epithelial Cells / Fatty Acids, Volatile Type of study: Prognostic_studies Limits: Humans Language: En Year: 2017 Type: Article

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