Dissection of mechanoresponse elements in promoter sites of the mechanoresponsive CYR61 gene.

Seefried, Lothar; Müller-Deubert, Sigrid; Krug, Melanie; Youssef, Almoatazbellah; Schütze, Norbert; Ignatius, Anita; Jakob, Franz; Ebert, Regina

Seefried, Lothar; Müller-Deubert, Sigrid; Krug, Melanie; Youssef, Almoatazbellah; Schütze, Norbert; Ignatius, Anita; Jakob, Franz; Ebert, Regina.

Affiliation

Seefried L; Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Müller-Deubert S; Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Krug M; Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Youssef A; Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Schütze N; Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Ignatius A; Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany.
Jakob F; Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Ebert R; Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany. Electronic address: r-ebert.klh@uni-wuerzburg.de.

Exp Cell Res ; 354(2): 103-111, 2017 05 15.

Article in En | MEDLINE | ID: mdl-28322825

Subject(s)

Cysteine-Rich Protein 61/genetics; Mechanotransduction, Cellular/genetics; Promoter Regions, Genetic; Base Sequence; Cell Line; Cloning, Molecular; Computer Simulation; Cyclic AMP Response Element-Binding Protein/metabolism; Cysteine-Rich Protein 61/metabolism; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Genes, Reporter; HEK293 Cells; Humans; Luciferases/metabolism; Protein Binding; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sequence Deletion; Stress, Mechanical; Telomerase/metabolism; Transgenes

Key words

Mechanotransduction; Promoter analysis; Telomerase-immortalised mesenchymal stem cells; hCyr61

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Full text: 1 Database: MEDLINE Main subject: Promoter Regions, Genetic / Mechanotransduction, Cellular / Cysteine-Rich Protein 61 Type of study: Prognostic_studies Limits: Humans Language: En Year: 2017 Type: Article

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