Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA.
Bioconjug Chem
; 28(4): 1214-1220, 2017 04 19.
Article
in En
| MEDLINE
| ID: mdl-28332825
ABSTRACT
Mono- and diaminated 2'-amino-LNA monomers were synthesized and introduced into oligonucleotides. Each modification imparts significant stabilization of nucleic acid duplexes and triplexes, excellent sequence selectivity, and significant nuclease resistance. Molecular modeling suggested that structural stabilization occurs via intrastrand electrostatic attraction between the protonated amino groups of the aminated 2'-amino-LNA monomers and the host oligonucleotide backbone.
Full text:
1
Database:
MEDLINE
Main subject:
Oligonucleotides
Language:
En
Year:
2017
Type:
Article