Utility of PET/CT After Cryoablation for Early Identification of Local Tumor Progression in Osseous Metastatic Disease.
AJR Am J Roentgenol
; 208(6): 1342-1351, 2017 Jun.
Article
in En
| MEDLINE
| ID: mdl-28333548
ABSTRACT
OBJECTIVE:
The purpose of this study is to evaluate the utility of combined PET/CT for the detection of early local tumor progression after cryoablation of bone metastases. MATERIALS ANDMETHODS:
A retrospective single-institution review revealed 61 consecutive patients with 80 separate bone metastases treated with cryoablation who were evaluated with a preablation PET/CT and at least two postablation PET/CT examinations between September 2007 and July 2015. Patients were excluded if they had local therapy or pathologic fracture after ablation. The patients were grouped according to postcryoablation disease status (i.e., local tumor progression or not) and PET radiotracer (i.e., 11C-choline or 18F-FDG) used. The maximum standardized uptake value (SUVmax) ratio (i.e., ratio of SUVmax to blood pool) was calculated within each osseous metastasis before and after cryoablation, and these were then compared between groups.RESULTS:
Of the 61 patients and 80 ablations performed, 32 patients were imaged with FDG PET/CT and 29 were imaged with 11C-choline PET/CT. Twenty-three patients imaged with FDG and 13 patients imaged with 11C-choline had evidence of local tumor progression on all postablation PET/CT examinations. The SUVmax ratio was significantly higher in patients with local tumor progression on the first and most remote postcryoablation PET/CT examinations for both FDG and 11C-choline (p < 0.001 in all cases). There was no significant difference in the postablation systemic therapy between the groups with and without local tumor progression.CONCLUSION:
Increased SUVmax ratio in patients after cryoablation for osseous metastatic disease should raise concern about local tumor progression independently of time after ablation.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Bone Neoplasms
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Cryosurgery
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Positron Emission Tomography Computed Tomography
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Neoplasm Recurrence, Local
Type of study:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Screening_studies
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Language:
En
Year:
2017
Type:
Article