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In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.
Yin, Chaoran; Zhang, Ting; Qu, Xiying; Zhang, Yonggang; Putatunda, Raj; Xiao, Xiao; Li, Fang; Xiao, Weidong; Zhao, Huaqing; Dai, Shen; Qin, Xuebin; Mo, Xianming; Young, Won-Bin; Khalili, Kamel; Hu, Wenhui.
Affiliation
  • Yin C; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Zhang T; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Qu X; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
  • Zhang Y; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Putatunda R; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Xiao X; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Li F; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Xiao W; Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Zhao H; Department of Clinical Science, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Dai S; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Qin X; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
  • Mo X; Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
  • Young WB; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: bioimaging@mail.com.
  • Khalili K; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address: kamel.khalili@temple.edu.
  • Hu W; Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address: whu@temple.edu.
Mol Ther ; 25(5): 1168-1186, 2017 05 03.
Article in En | MEDLINE | ID: mdl-28366764
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Full text: 1 Database: MEDLINE Main subject: Genetic Therapy / HIV Infections / HIV-1 / Proviruses / Genome, Viral / RNA, Guide, Kinetoplastida / Endonucleases Limits: Animals / Humans Language: En Year: 2017 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Genetic Therapy / HIV Infections / HIV-1 / Proviruses / Genome, Viral / RNA, Guide, Kinetoplastida / Endonucleases Limits: Animals / Humans Language: En Year: 2017 Type: Article