The effects of a novel series of selective inhibitors of arachidonate 5-lipoxygenase on anaphylactic and inflammatory responses.

Bhattacherjee, P; Boughton-Smith, N K; Follenfant, R L; Garland, L G; Higgs, G A; Hodson, H F; Islip, P J; Jackson, W P; Moncada, S; Payne, A N

Bhattacherjee, P; Boughton-Smith, N K; Follenfant, R L; Garland, L G; Higgs, G A; Hodson, H F; Islip, P J; Jackson, W P; Moncada, S; Payne, A N.

Affiliation

Bhattacherjee P; Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.

Ann N Y Acad Sci ; 524: 307-20, 1988.

Article in En | MEDLINE | ID: mdl-2837965

Subject(s)

Anaphylaxis/metabolism; Arachidonate Lipoxygenases/antagonists & inhibitors; Arachidonic Acids/metabolism; Hydroxamic Acids/pharmacology; Lipoxygenase Inhibitors; 5,8,11,14-Eicosatetraynoic Acid/pharmacology; Anaphylaxis/physiopathology; Animals; Arachidonate 5-Lipoxygenase/metabolism; Arachidonic Acid; Bronchial Provocation Tests; Bronchial Spasm/physiopathology; Fever/physiopathology; Gastric Mucosa/drug effects; Guinea Pigs; Humans; Inflammation; Leukocytes/enzymology; Leukotriene B4/physiology; Masoprocol/pharmacology; Rats; SRS-A/physiology

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Database: MEDLINE Main subject: Arachidonate Lipoxygenases / Arachidonic Acids / Lipoxygenase Inhibitors / Hydroxamic Acids / Anaphylaxis Limits: Animals / Humans Language: En Year: 1988 Type: Article

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