A Role of Metastable Regions and Their Connectivity in the Inactivation of a Redox-Regulated Chaperone and Its Inter-Chaperone Crosstalk.

Rimon, Oded; Suss, Ohad; Goldenberg, Mor; Fassler, Rosi; Yogev, Ohad; Amartely, Hadar; Propper, Guy; Friedler, Assaf; Reichmann, Dana

Rimon, Oded; Suss, Ohad; Goldenberg, Mor; Fassler, Rosi; Yogev, Ohad; Amartely, Hadar; Propper, Guy; Friedler, Assaf; Reichmann, Dana.

Affiliation

Rimon O; 1 Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem , Jerusalem, Israel .
Suss O; 1 Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem , Jerusalem, Israel .
Goldenberg M; 1 Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem , Jerusalem, Israel .
Fassler R; 1 Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem , Jerusalem, Israel .
Yogev O; 1 Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem , Jerusalem, Israel .
Amartely H; 2 Institute of Chemistry, The Hebrew University of Jerusalem , Safra Campus Givat Ram, Jerusalem, Israel .
Propper G; 1 Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem , Jerusalem, Israel .
Friedler A; 2 Institute of Chemistry, The Hebrew University of Jerusalem , Safra Campus Givat Ram, Jerusalem, Israel .
Reichmann D; 1 Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem , Jerusalem, Israel .

Antioxid Redox Signal ; 27(15): 1252-1267, 2017 Nov 20.

Article in En | MEDLINE | ID: mdl-28394178

Subject(s)

Bacteria/metabolism; Heat-Shock Proteins/chemistry; Heat-Shock Proteins/metabolism; Bacteria/genetics; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Heat-Shock Proteins/genetics; Models, Molecular; Oxidative Stress; Protein Conformation; Protein Stability

Key words

ATP-independent chaperone; Hsp33; intrinsically disordered proteins; protein thiol switches; redox-regulated chaperone

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