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SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer.
Ichihara, Eiki; Westover, David; Meador, Catherine B; Yan, Yingjun; Bauer, Joshua A; Lu, Pengcheng; Ye, Fei; Kulick, Amanda; de Stanchina, Elisa; McEwen, Robert; Ladanyi, Marc; Cross, Darren; Pao, William; Lovly, Christine M.
Affiliation
  • Ichihara E; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • Westover D; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • Meador CB; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • Yan Y; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • Bauer JA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • Lu P; Institute of Chemical Biology, High-Throughput Screening Facility, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • Ye F; Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • Kulick A; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • de Stanchina E; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • McEwen R; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Ladanyi M; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Cross D; AstraZeneca Oncology, Cambridge, United Kingdom.
  • Pao W; Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Lovly CM; AstraZeneca Oncology, Cambridge, United Kingdom.
Cancer Res ; 77(11): 2990-3000, 2017 06 01.
Article in En | MEDLINE | ID: mdl-28416483
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Src-Family Kinases / Focal Adhesion Protein-Tyrosine Kinases / Lung Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Src-Family Kinases / Focal Adhesion Protein-Tyrosine Kinases / Lung Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2017 Type: Article