An HLA-B7-specific antibody in an HLA-B*07 positive patient explained by a nonexpressed allele (HLA-B*07:181N).
HLA
; 90(1): 32-35, 2017 07.
Article
in En
| MEDLINE
| ID: mdl-28417556
ABSTRACT
Antibody identification by a bead array assay in a kidney patient revealed several HLA-specific antibodies including one directed against the HLA-B7 antigen. Low-resolution typing of the patient indicated the presence of an HLA-B*07 allele. To rule out an HLA-specific autoantibody the HLA-typing of the patient was further refined by nucleotide sequencing on a next-generation sequencing platform and eventually showed an HLA-B*39010103 and HLA-B*07181N genotype. Thereby the allospecific nature of the antibody was proven. The HLA-B7-specific antibody could be explained by an immunization during the first kidney-transplantation in 1996 with an HLA-B*07 positive donor. When assessing the plausibility of antibodies, the presence of nonexpressed alleles should be taken into consideration.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
HLA-B7 Antigen
/
Kidney Transplantation
/
Alleles
/
HLA-B39 Antigen
/
Transplant Recipients
/
Isoantibodies
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Year:
2017
Type:
Article