Alpha-1 Antitrypsin Levels and Polymorphisms in Interstitial Lung Diseases.
Turk J Med Sci
; 47(2): 476-482, 2017 Apr 18.
Article
in En
| MEDLINE
| ID: mdl-28425234
ABSTRACT
BACKGROUND/AIM:
Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis. We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease. MATERIALS ANDMETHODS:
A total of 103 interstitial lung disease patients were compared.RESULTS:
The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13). Low alpha-1 antitrypsin levels were more frequently observed in nonidiopathic interstitial pneumonia patients compared with idiopathic interstitial pneumonia, but the difference was not statistically significant (8.9% vs. 0%, respectively, P = 0.4). In 100 patients, the normal PiMM genotype was detected, while abnormal ones (PiMZ, n = 2, 1.9%; PiMS, n = 1, 0.97%) were determined in three cases. When the frequency of alpha-1 antitrypsin polymorphism in interstitial lung disease patients was compared with the data of the healthy population, no significant difference was detected for the PiMZ and PiMS variants (P = 0.15 and P = 0.44, respectively).CONCLUSION:
Lower levels of serum alpha-1 antitrypsin were more frequent in nonidiopathic interstitial pneumonia patients than idiopathic interstitial pneumonia without an increase in genetic polymorphism. The difference was not statistically significant.
Full text:
1
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Alpha 1-Antitrypsin
/
Lung Diseases, Interstitial
/
Alpha 1-Antitrypsin Deficiency
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Year:
2017
Type:
Article