Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response.
Environ Toxicol Pharmacol
; 52: 183-187, 2017 Jun.
Article
in En
| MEDLINE
| ID: mdl-28433805
ABSTRACT
Exposure to inorganic arsenic (iAs) in drinking water is a global public health concern and is associated with a range of health outcomes, including immune dysfunction. Children are a particularly sensitive population to the effects of inorganic arsenic, yet the biological mechanisms underlying adverse health outcomes are understudied. Here we used a proteomic approach to examine the effects of iAs exposure on circulating serum protein levels in a cross-sectional children's cohort in Mexico. To identify iAs-associated proteins, levels of total urinary arsenic (U-tAs) and its metabolites were determined and serum proteins assessed for differences in expression. The results indicate an enrichment of Tumor Necrosis Factor-(TNF)-regulated immune and inflammatory response proteins that displayed decreased expression levels in relation to increasing U-tAs. Notably, when analyzed in the context of the proportions of urinary arsenic metabolites in children, the most robust response was observed in relation to the monomethylated arsenicals. This study is among the first serum proteomics assessment in children exposed to iAs.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Arsenic
/
Blood Proteins
/
Environmental Exposure
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
En
Year:
2017
Type:
Article