Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor.

Hinson, Shannon R; Clift, Ian C; Luo, Ningling; Kryzer, Thomas J; Lennon, Vanda A

Hinson, Shannon R; Clift, Ian C; Luo, Ningling; Kryzer, Thomas J; Lennon, Vanda A.

Affiliation

Hinson SR; Neuroimmunology Laboratory, Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN 55905.
Clift IC; Neuroimmunology Laboratory, Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN 55905.
Luo N; Neuroimmunology Laboratory, Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN 55905.
Kryzer TJ; Neuroimmunology Laboratory, Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN 55905.
Lennon VA; Neuroimmunology Laboratory, Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN 55905; lennon.vanda@mayo.edu.

Proc Natl Acad Sci U S A ; 114(21): 5491-5496, 2017 05 23.

Article in En | MEDLINE | ID: mdl-28461494

Subject(s)

Aquaporin 4/metabolism; Astrocytes/metabolism; Excitatory Amino Acid Transporter 2/metabolism; Neuromyelitis Optica/immunology; Receptors, IgG/metabolism; Animals; Aquaporin 4/immunology; Case-Control Studies; Female; Humans; Immunoglobulin G/metabolism; Interleukin-6/metabolism; Mice, Inbred C57BL; Pregnancy; Primary Cell Culture; Rats, Inbred Lew; Rats, Sprague-Dawley

Key words

CD32; CD64; autoimmune astrocytopathy; neuromyelitis optica; pathogenic IgG

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Full text: 1 Database: MEDLINE Main subject: Astrocytes / Neuromyelitis Optica / Receptors, IgG / Excitatory Amino Acid Transporter 2 / Aquaporin 4 Type of study: Observational_studies / Prognostic_studies Limits: Animals / Female / Humans / Pregnancy Language: En Year: 2017 Type: Article

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