Genomic epidemiology of global VIM-producing Enterobacteriaceae.
J Antimicrob Chemother
; 72(8): 2249-2258, 2017 08 01.
Article
in En
| MEDLINE
| ID: mdl-28520983
ABSTRACT
Background:
International data on the molecular epidemiology of Enterobacteriaceae with VIM carbapenemases are limited.Methods:
We performed short read (Illumina) WGS on a global collection of 89 VIM-producing clinical Enterobacteriaceae (2008-14).Results:
VIM-producing (11 varieties within 21 different integrons) isolates were mostly obtained from Europe. Certain integrons with bla VIM were specific to a country in different species and clonal complexes (CCs) (In 87 , In 624 , In 916 and In 1323 ), while others had spread globally among various Enterobacteriaceae species (In 110 and In 1209 ). Klebsiella pneumoniae was the most common species ( n = 45); CC147 from Greece was the most prevalent clone and contained In 590 -like integrons with four different bla VIM s. Enterobacter cloacae complex was the second most common species and mainly consisted of Enterobacter hormaechei ( Enterobacter xiangfangensis , subsp. steigerwaltii and Hoffmann cluster III). CC200 (from Croatia and Turkey), CC114 (Croatia, Greece, Italy and the USA) and CC78 (from Greece, Italy and Spain) containing bla VIM-1 were the most common clones among the E. cloacae complex.Conclusions:
This study highlights the importance of surveillance programmes using the latest molecular techniques in providing insight into the characteristics and global distribution of Enterobacteriaceae with bla VIM s.
Full text:
1
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Beta-Lactamases
/
Molecular Epidemiology
/
Enterobacteriaceae
/
Enterobacteriaceae Infections
Type of study:
Screening_studies
Limits:
Humans
Language:
En
Year:
2017
Type:
Article