Dual Protective Effects of Flavonoids from Petasites japonicus against UVB-Induced Apoptosis Mediated via HSF-1 Activated Heat Shock Proteins and Nrf2-Activated Heme Oxygenase-1 Pathways.

Kim, Ki Mo; Im, A-Rang; Lee, Sanghyun; Chae, Sungwook

Kim, Ki Mo; Im, A-Rang; Lee, Sanghyun; Chae, Sungwook.

Affiliation

Kim KM; KM Convergence Research Division, Korea Institute of Oriental Medicine.
Im AR; University of Science and Technology.
Lee S; KM Convergence Research Division, Korea Institute of Oriental Medicine.
Chae S; Department of Integrative Plant Science, Chung-Ang University.

Biol Pharm Bull ; 40(6): 765-773, 2017.

Article in En | MEDLINE | ID: mdl-28566621

Subject(s)

Flavonoids/pharmacology; Heat Shock Transcription Factors/metabolism; Heme Oxygenase-1/metabolism; NF-E2-Related Factor 2/metabolism; Petasites; Radiation-Protective Agents/pharmacology; Ultraviolet Rays/adverse effects; Apoptosis/drug effects; Apoptosis/radiation effects; Cell Line; Cell Survival/drug effects; HSP70 Heat-Shock Proteins/genetics; HSP70 Heat-Shock Proteins/metabolism; Heat-Shock Proteins/metabolism; Heme Oxygenase-1/genetics; Humans; Plant Extracts/chemistry; Plant Leaves/chemistry; Signal Transduction/drug effects

Key words

Petasites japonicus; UVB radiation; antioxidant response element; apoptosis; heat-shock response transcription element; heme oxygenase-1

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Full text: 1 Database: MEDLINE Main subject: Radiation-Protective Agents / Ultraviolet Rays / Flavonoids / Petasites / Heme Oxygenase-1 / NF-E2-Related Factor 2 / Heat Shock Transcription Factors Type of study: Prognostic_studies Limits: Humans Language: En Year: 2017 Type: Article

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