Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2.

Das, Sreedam C; Morales, Rodrigo A V; Seow, Jeffrey; Krishnarjuna, Bankala; Dissanayake, Ravindu; Anders, Robin F; MacRaild, Christopher A; Norton, Raymond S.

Affiliation

Das SC; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Morales RAV; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Seow J; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Krishnarjuna B; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Dissanayake R; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
Anders RF; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
MacRaild CA; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Norton RS; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

FEBS J ; 284(16): 2649-2662, 2017 08.

Article in En | MEDLINE | ID: mdl-28618199

Subject(s)

Antigens, Protozoan/immunology; Protozoan Proteins/immunology; Antigens, Protozoan/chemistry; Enzyme-Linked Immunosorbent Assay; Liposomes/chemistry; Magnetic Resonance Spectroscopy; Plasmodium falciparum/immunology; Protozoan Proteins/chemistry

Key words

antigenicity; lipid interaction; liposome; malaria; merozoite surface protein 2