Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos.
J Assist Reprod Genet
; 34(9): 1173-1178, 2017 Sep.
Article
in En
| MEDLINE
| ID: mdl-28676910
ABSTRACT
PURPOSE:
This study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status.METHODS:
Patients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subjected to trophectoderm biopsy and microarray comparative genomic hybridization (array-CGH). Blastocyst development process was analyzed using time-lapse images.RESULTS:
Morphokinetic parameters tPNf, t2, t3, t4, t5, t8, t9, tcom, tM, tSB, tB, tEB, CC1, CC2, CC3, S2, S3, t5-t2, and tB-tSB showed no significant difference in euploid embryos compared to aneuploid counterparts. In addition, two risk models based on previously published morphokinetic parameters failed to segregate euploid from aneuploid embryos.CONCLUSIONS:
Morphokinetic parameters subjected to investigation in the present study failed to improve the chance of selecting euploid embryos.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Fertilization in Vitro
/
Embryonic Development
/
Time-Lapse Imaging
/
Aneuploidy
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Year:
2017
Type:
Article