Ovotoxicity of cigarette smoke: A systematic review of the literature.
Reprod Toxicol
; 72: 164-181, 2017 09.
Article
in En
| MEDLINE
| ID: mdl-28684319
ABSTRACT
This study reviews the scientific literature on the noxious effects of cigarette smoke on the ovarian follicle, and the cumulative data on the impact of smoking on in vitro fertilization (IVF) cycle outcome. There is a close association between tobacco smoke and accelerated follicle loss, abnormal follicle growth and impairment of oocyte morphology and maturation. There is an increasing amount of evidence indicating that smoke can directly derange folliculogenesis. Increased cellular apoptosis or autophagy, DNA damage and abnormal crosstalk between oocyte and granulosa cells have been implicated in the demise of ovarian follicles. It becomes increasingly clear that maternal smoking can exert multigenerational effects on the ovarian function of the progeny. Growing evidence suggests that cigarette smoke is associated with decreased results after IVF. Further research is needed to better define the molecular mechanisms behind smoking-induced ovarian disruption.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Oocytes
/
Smoke
/
Tobacco Products
/
Ovarian Follicle
Type of study:
Systematic_reviews
Limits:
Animals
/
Female
/
Humans
Language:
En
Year:
2017
Type:
Article