A "Prozone-Like" Effect Influences the Efficacy of the Monoclonal Antibody ABT-700 against the Hepatocyte Growth Factor Receptor.

Vaidya, Kedar S; Oleksijew, Anatol; Tucker, Lora A; Pappano, William N; Anderson, Mark G; Grinnell, Christine M; Zhang, Qian; Heighton, Sarah J; Mitten, Michael J; Mishra, Sasmita; Palma, Joann P; Wang, Jieyi; Reilly, Edward B; Boghaert, Erwin R

Vaidya, Kedar S; Oleksijew, Anatol; Tucker, Lora A; Pappano, William N; Anderson, Mark G; Grinnell, Christine M; Zhang, Qian; Heighton, Sarah J; Mitten, Michael J; Mishra, Sasmita; Palma, Joann P; Wang, Jieyi; Reilly, Edward B; Boghaert, Erwin R.

Affiliation

Vaidya KS; Oncology Discovery, AbbVie Inc., North Chicago, IL, USA.

Pharmacology ; 100(5-6): 229-242, 2017.

Article in En | MEDLINE | ID: mdl-28743107

Subject(s)

Antibodies, Monoclonal/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Hepatocytes/drug effects; Hepatocytes/metabolism; Proto-Oncogene Proteins c-met/metabolism; Animals; Cell Line; Cisplatin/administration & dosage; Humans; Mice; Mice, Nude; Mice, SCID

Key words

ABT-700; Bivalent binding; Hepatocyte growth factor receptor; Prozone; Tumor burden

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Full text: 1 Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Proto-Oncogene Proteins c-met / Hepatocytes / Antibodies, Monoclonal Limits: Animals / Humans Language: En Year: 2017 Type: Article

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