Mechanism of Enzyme Repair by the AAA<sup>+</sup> Chaperone Rubisco Activase.

Bhat, Javaid Y; Milicic, Goran; Thieulin-Pardo, Gabriel; Bracher, Andreas; Maxwell, Andrew; Ciniawsky, Susanne; Mueller-Cajar, Oliver; Engen, John R; Hartl, F Ulrich; Wendler, Petra; Hayer-Hartl, Manajit

Mechanism of Enzyme Repair by the AAA⁺ Chaperone Rubisco Activase.

Bhat, Javaid Y; Milicic, Goran; Thieulin-Pardo, Gabriel; Bracher, Andreas; Maxwell, Andrew; Ciniawsky, Susanne; Mueller-Cajar, Oliver; Engen, John R; Hartl, F Ulrich; Wendler, Petra; Hayer-Hartl, Manajit.

Affiliation

Bhat JY; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Milicic G; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Thieulin-Pardo G; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Bracher A; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Maxwell A; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Ciniawsky S; Gene Center Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
Mueller-Cajar O; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Engen JR; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115-5000, USA.
Hartl FU; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Wendler P; Gene Center Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. Electronic address: petra.wendler@uni-potsdam.de.
Hayer-Hartl M; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. Electronic address: mhartl@biochem.mpg.de.

Mol Cell ; 67(5): 744-756.e6, 2017 Sep 07.

Article in En | MEDLINE | ID: mdl-28803776

Subject(s)

Bacterial Proteins/metabolism; Molecular Chaperones/metabolism; Plant Proteins/metabolism; Rhodobacter sphaeroides/enzymology; Ribulose-Bisphosphate Carboxylase/metabolism; Tissue Plasminogen Activator/metabolism; Adenosine Triphosphate/metabolism; Allosteric Regulation; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Binding Sites; Catalytic Domain; Cross-Linking Reagents/chemistry; Deuterium Exchange Measurement; Enzyme Stability; Molecular Chaperones/chemistry; Molecular Chaperones/genetics; Molecular Docking Simulation; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; Protein Subunits; Rhodobacter sphaeroides/genetics; Ribulose-Bisphosphate Carboxylase/chemistry; Ribulose-Bisphosphate Carboxylase/genetics; Structure-Activity Relationship; Time Factors; Tissue Plasminogen Activator/chemistry; Tissue Plasminogen Activator/genetics

Key words

AAA+ protein; Rubisco; Rubisco activase; crosslinking; cryo-electron microscopy; hydrogen/deuterium exchange; mass spectrometry

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Full text: 1 Database: MEDLINE Main subject: Plant Proteins / Ribulose-Bisphosphate Carboxylase / Bacterial Proteins / Rhodobacter sphaeroides / Tissue Plasminogen Activator / Molecular Chaperones Language: En Year: 2017 Type: Article

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