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Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.
Zha, Li; Jiang, Yindi; Henke, Matthew T; Wilson, Matthew R; Wang, Jennifer X; Kelleher, Neil L; Balskus, Emily P.
Affiliation
  • Zha L; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Jiang Y; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Henke MT; Department of Chemistry, Northwestern University, Evanston, Illinois, USA.
  • Wilson MR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Wang JX; Small Molecule Mass Spectrometry Facility, FAS Division of Science, Cambridge, Massachusetts, USA.
  • Kelleher NL; Department of Chemistry, Northwestern University, Evanston, Illinois, USA.
  • Balskus EP; Department of Molecular Biosciences and the Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA.
Nat Chem Biol ; 13(10): 1063-1065, 2017 Oct.
Article in En | MEDLINE | ID: mdl-28805802
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Full text: 1 Database: MEDLINE Main subject: Peptide Synthases / Peptides / S-Adenosylmethionine / Cyclopropanes / Polyketides Language: En Year: 2017 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Peptide Synthases / Peptides / S-Adenosylmethionine / Cyclopropanes / Polyketides Language: En Year: 2017 Type: Article