Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits.
J Chem Inf Model
; 57(9): 2143-2151, 2017 09 25.
Article
in En
| MEDLINE
| ID: mdl-28813151
ABSTRACT
Identification of new hits is one of the biggest challenges in drug discovery. Creating a library of well-characterized drug-like compounds is a key step in this process. Our group has developed an in-house chemical library called the Medicinal and Biological Chemistry (MBC) library. This collection has been successfully used to start several medicinal chemistry programs and developed in an accumulation of more than 30 years of experience in drug design and discovery of new drugs for unmet diseases. It contains over 1000 compounds, mainly heterocyclic scaffolds. In this work, analysis of drug-like properties and comparative study with well-known libraries by using different computer software are presented here.
Full text:
1
Database:
MEDLINE
Main subject:
Computational Biology
/
Drug Discovery
/
Databases, Pharmaceutical
Limits:
Humans
Language:
En
Year:
2017
Type:
Article