Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways.

Borrie, Sarah C; Brems, Hilde; Legius, Eric; Bagni, Claudia

Borrie, Sarah C; Brems, Hilde; Legius, Eric; Bagni, Claudia.

Affiliation

Borrie SC; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
Brems H; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
Legius E; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
Bagni C; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.

Annu Rev Genomics Hum Genet ; 18: 115-142, 2017 08 31.

Article in En | MEDLINE | ID: mdl-28859574

Subject(s)

Cognitive Dysfunction/physiopathology; Intellectual Disability/metabolism; Intellectual Disability/psychology; Neuronal Plasticity; Signal Transduction; Animals; Cognitive Dysfunction/metabolism; Disease Models, Animal; Humans; Intellectual Disability/physiopathology; Mice; TOR Serine-Threonine Kinases

Key words

FXS; Rasopathy; autism; learning disabilities; mTOR; synaptic plasticity

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Cognitive Dysfunction / Intellectual Disability / Neuronal Plasticity Limits: Animals / Humans Language: En Year: 2017 Type: Article

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