Antineoplastic Agents/chemical synthesis; Chelating Agents/chemistry; Drug Discovery; Levofloxacin/chemical synthesis; Nucleic Acid Synthesis Inhibitors/chemical synthesis; Pemetrexed/chemical synthesis; Prodrugs/chemical synthesis; Administration, Oral; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/chemistry; Antineoplastic Agents/metabolism; Esters/administration & dosage; Esters/chemical synthesis; Esters/chemistry; Esters/metabolism; Gastrointestinal Microbiome; Gastrointestinal Tract/metabolism; Humans; Hydrolysis; Levofloxacin/administration & dosage; Levofloxacin/chemistry; Levofloxacin/metabolism; Nucleic Acid Synthesis Inhibitors/administration & dosage; Nucleic Acid Synthesis Inhibitors/chemistry; Nucleic Acid Synthesis Inhibitors/metabolism; Pemetrexed/administration & dosage; Pemetrexed/chemistry; Pemetrexed/metabolism; Prodrugs/administration & dosage; Prodrugs/chemistry; Prodrugs/metabolism; Rats

hemiacetal prodrug; levofloxacin; oral pemetrexed; pemetrexed dimedoxomil; prodrug of levofloxacin; prodrug of pemetrexed