Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea.
Org Biomol Chem
; 15(35): 7411-7421, 2017 Sep 13.
Article
in En
| MEDLINE
| ID: mdl-28872169
ABSTRACT
The volatiles emitted by five fungal strains previously isolated from the marine sponge Callyspongia cf. flammea were captured with a closed-loop stripping apparatus (CLSA) and analyzed by GC-MS. Besides several widespread compounds, a series of metabolites with interesting bioactivities were found, including the quorum sensing inhibitor protoanemonin, the fungal phytotoxin 3,4-dimethylpentan-4-olide, and the insect attractant 1,2,4-trimethoxybenzene. In addition, the aromatic polyketides isotorquatone and chartabomone that are both known from Eucalyptus and a new O-desmethyl derivative were identified. The biosynthesis of isotorquatone was studied by feeding experiments with isotopically labeled precursors and its absolute configuration was determined by enantioselective synthesis of a reference compound. Bioactivity testings showed algicidal activity for some of the identified compounds, suggesting a potential ecological function in sponge defence.
Full text:
1
Database:
MEDLINE
Main subject:
Callyspongia
/
Volatile Organic Compounds
/
Mycobiome
Limits:
Animals
Language:
En
Year:
2017
Type:
Article