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A Single Amino Acid Substitution in the Third Transmembrane Region Has Opposite Impacts on the Selectivity of the Parasiticides Fluralaner and Ivermectin for Ligand-Gated Chloride Channels.
Nakata, Yunosuke; Fuse, Toshinori; Yamato, Kohei; Asahi, Miho; Nakahira, Kunimitsu; Ozoe, Fumiyo; Ozoe, Yoshihisa.
Affiliation
  • Nakata Y; Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan (Y.N., T.F., K.Y, F.O., Y.O.); and Biological Research Laboratories, Nissan Chemical Industries, Ltd., Saitama, Japan (M.A., K.N.).
  • Fuse T; Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan (Y.N., T.F., K.Y, F.O., Y.O.); and Biological Research Laboratories, Nissan Chemical Industries, Ltd., Saitama, Japan (M.A., K.N.).
  • Yamato K; Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan (Y.N., T.F., K.Y, F.O., Y.O.); and Biological Research Laboratories, Nissan Chemical Industries, Ltd., Saitama, Japan (M.A., K.N.).
  • Asahi M; Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan (Y.N., T.F., K.Y, F.O., Y.O.); and Biological Research Laboratories, Nissan Chemical Industries, Ltd., Saitama, Japan (M.A., K.N.).
  • Nakahira K; Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan (Y.N., T.F., K.Y, F.O., Y.O.); and Biological Research Laboratories, Nissan Chemical Industries, Ltd., Saitama, Japan (M.A., K.N.).
  • Ozoe F; Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan (Y.N., T.F., K.Y, F.O., Y.O.); and Biological Research Laboratories, Nissan Chemical Industries, Ltd., Saitama, Japan (M.A., K.N.).
  • Ozoe Y; Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan (Y.N., T.F., K.Y, F.O., Y.O.); and Biological Research Laboratories, Nissan Chemical Industries, Ltd., Saitama, Japan (M.A., K.N.) ozoe-y@life.shimane-u.ac.jp.
Mol Pharmacol ; 92(5): 546-555, 2017 11.
Article in En | MEDLINE | ID: mdl-28887352
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Full text: 1 Database: MEDLINE Main subject: Ivermectin / Chloride Channels / Amino Acid Substitution / Ligand-Gated Ion Channels / Isoxazoles / Antiparasitic Agents Type of study: Prognostic_studies Limits: Animals Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Ivermectin / Chloride Channels / Amino Acid Substitution / Ligand-Gated Ion Channels / Isoxazoles / Antiparasitic Agents Type of study: Prognostic_studies Limits: Animals Language: En Year: 2017 Type: Article